The medication for irritable bowel syndrome is mainly based on symptomatic links, and there is no exact and latest effective drug. Firstly, hydrocolloids are able to absorb water, increase the volume of stool and make it loose and soft. Therefore, they are suitable for patients with both diarrhea and constipation, especially for irritable bowel syndrome with alternating diarrhea and constipation. Second, pivetonium bromide, for selective action, as calcium antagonist of the smooth muscle of the gastrointestinal tract, mainly for those with significant abdominal pain. Third, the pro-gastrointestinal motility drugs, such as domperidone, mosapride, for abdominal distension, constipation. Fourth, antidiarrheal drugs, such as Emmenagogue, compound difenoxanthin, for diarrhea, serious people can be used for a short period of time. Fifthly, probiotics, such as Pepcid, lactobacillus tablets, rectify intestinal flora, etc. are mainly used to adjust the intestinal flora, and some patients may also have an effect. Lastly, antidepressants, anti-anxiety drugs and various other psychological treatments. The vast majority of patients with severe irritable bowel syndrome have significant psychosomatic disorders, so this is something that needs to be fully recognized.