Patients with chronic lymphocytic leukemia should avoid cold, fried and spicy foods. 1. Chronic lymphocytic leukemia is a kind of malignant tumor originated from hematopoietic tissues. Patients should pay attention to food hygiene during eating and avoid eating raw, cold, overnight or spoiled food. Fish spines should be removed before eating fish food to prevent hard objects from piercing the oral mucosa leading to mouth ulcers, thus increasing the risk of localized infections. 2. Patients should also pay attention to the reasonable combination of dietary structure, avoid eating fried and spicy stimulating food, eat more easily digestible food and vitamin-rich vegetables and fruits. For patients with poor defecation habits and constipation, they should pay more attention to the supplementation of fibrous food, and try to maintain smooth defecation to prevent constipation from triggering hemorrhoids, anal fissure, etc., which will also increase the risk of local infection. Chronic lymphocytic leukemia patients, in addition to avoiding food, should also be appropriate fitness activities, reasonable arrangements for rest, pay attention to physical hygiene and actively cooperate with the doctor’s treatment, which is more conducive to the recovery of the condition.