The difference between Clindamycin and Amoxicillin Clavulanate Potassium includes different ingredients, different categories, different indications and different adverse reactions. 1. Different ingredients: the main ingredient of clindamycin is clindamycin phosphate; the main ingredient of amoxicillin potassium clavulanate is amoxicillin and clavulanic acid. 2. Different categories: Clindamycin, also known as erythromycin, belongs to the macrolide class of drugs, and erythromycin is the same kind of drug; Amoxicillin Clavulanate Potassium Amoxicillin belongs to the penicillin class of drugs, and penicillin belongs to the same class of drugs. 3. Different indications: Clindamycin is suitable for gram-positive bacteria and anaerobic bacteria induced by a variety of infectious diseases, for lincomycin allergy is prohibited; Amoxicillin Clavulanate Potassium belongs to the treatment of microorganisms sensitive strains of bacteria induced by infectious diseases, penicillin drugs are prohibited for those who are allergic. In addition, the above drugs are taken with certain risks, patients need to get the guidance of a specialist.