Occupational lesions in the upper part of the bile duct are mostly caused by bile duct stones, of course, the possibility of bile duct tumor or bile duct cancer can not be ruled out, and relevant examinations should be completed to make a clear diagnosis. Patients with choledocholithiasis often have acute symptoms such as fever, severe pain, jaundice, etc. At this time, it is not suitable to carry out surgery, and should be treated with anti-inflammatory and anti-shock therapy, and then carry out endoscopic incision and extraction of stones or percutaneous hepatic perforation and drainage after stabilization of the condition. Bile duct tumors should be subjected to pathological biopsy to clarify the pathological results and guide the next step of treatment according to the pathological results. Occupational lesions in the upper part of the bile duct should be paid attention to, improve the relevant examination, make a diagnosis as soon as possible, and carry out the relevant treatment.