The use of corkscrew still can not be considered for the improper use of corkscrew or intestinal obstruction, intestinal polyps, intestinal cancer and other intestinal diseases caused by. 1. Improper use: when using corkscrew, it needs to be injected from the anus, and try to let the corkscrew contact the feces in the rectum, so as to play the role of lubricating feces and stimulating intestinal peristalsis; if the dosage is too small, the stimulation of the rectum is insufficient, and the phenomena of not having a bowel movement after the use of corkscrew may occur. If the dose is too small, the rectum may not be stimulated enough, and there may be no bowel movement after the use of Kesiclofenac. In addition, Kesiclofenac should be retained in the rectum for about 15 minutes after use in order to maximize its effect. If the retention time is too short, the effect of the drug will also be affected. 2. Intestinal diseases: such as intestinal obstruction, intestinal polyps, intestinal cancer and other diseases, can be due to intestinal tubes, polyps, cancerous tissues and other partial or complete obstruction of the intestinal lumen, resulting in feces can not pass through the intestinal tract, causing constipation, abdominal pain, abdominal distension and other symptoms, at this time the use of Keseloconjugate to relieve constipation is not effective. After the use of Keserol or can not pull, it is recommended that patients seek medical attention in order to clarify the diagnosis, under the guidance of the doctor to carry out targeted treatment. Drugs need to be used in accordance with medical advice.