The best treatment methods for long-term depressed mood are medication, self-adjustment treatment, and psychotherapy. Medication is also some special pessimism, disappointment, depressed mood, happy, and has been more than 2 weeks, has a clear tendency to depression, you can take drugs to intervene. Commonly used drugs include Chinese medicine, such as liver detoxification capsule, tranquilizer and brain tonic liquid, detoxification pill, etc. These drugs are all herbal extract preparations, which are more effective and relatively mild, with less side effects. There are also some antidepressants, commonly used are sertraline, fluoxetine, paroxetine, venlafaxine, etc. These drugs are selective 5-hydroxytryptamine reuptake inhibitors or dual-channel drugs, which are more effective and have relatively few side effects. As for self-adjustment treatment, in general, you must find out why you are depressed, such as work stress or interpersonal tension, or even possibly belong to the relationship between mother-in-law and daughter-in-law, economic pressure, emotional crisis, etc. If you have such a knot, you must learn to open your heart, while you have to adjust your lifestyle, try to devote yourself to your current life, learn to enrich yourself, appropriate exercise, such as running, etc. Psychotherapy is mainly to establish a good relationship with your own psychotherapist, you can choose the treatment methods are cognitive behavioral therapy, humanistic therapy, Morita therapy, family therapy, etc., you can choose the right method to do. If the long-term psychological depression is caused by family tensions, relationship problems with parents or children, you can choose family therapy, especially to bring their family members together to talk to a psychotherapist, while actively communicate, learn to adjust the relationship, learn to understand the attitude of others, these are very good and very useful methods.