As a specialist in the Habitual Miscarriage Clinic, I am confronted with a wide variety of patients with a history of adverse pregnancy and delivery, who usually come to me with a thick stack of test reports and even sobbing. In the process of treating them, I am more or less exposed to the drug aspirin. When it comes to aspirin, not only do patients resist the use of this drug during pregnancy, but many doctors even question my use of aspirin for pregnant women. What is aspirin? Aspirin, an antipyretic and analgesic drug, has anti-inflammatory and anti-rheumatic effects, inhibits platelet adhesion and aggregation, and prevents thrombosis. Knowing the role of aspirin, we know why aspirin is used to treat patients. Of course, our patients do not need to go for antipyretic and analgesic, but mainly for the latter two conditions: anti-inflammatory and anti-rheumatic and improving blood hypercoagulability. Which patients need aspirin? 1. Patients with a clear diagnosis of autoimmune disease and a history of adverse pregnancy and delivery as described above. 2.Patients with a clear diagnosis of easy embolism and a history of adverse pregnancy and delivery as described above. 3.Patients with abnormal uterine artery perfusion and placental perfusion, accounting for about 5-10% of outpatients. 4, other: hypertension, diabetes mellitus, kidney disease, some pregnancy combined with heart disease. What dose of aspirin should be used? Based on the physiological characteristics of Chinese women, it is proposed that the dose of aspirin during pregnancy can fluctuate from 25-100mg/day according to the platelet aggregation rate and the perfusion status of uterine artery and umbilical blood flow. Aspirin Dosage Precautions Aspirin, FDA pregnancy drug class C, is prone to pass through the placenta, and animal studies have shown that high dose application in the first trimester (>150 mg daily) can cause teratogenic fetuses, such as spina bifida, craniosynostosis, facial cleft, leg deformities, and hypoplasia of the central nervous system, internal organs, and bones. Long-term use in late pregnancy can cause constriction or premature closure of the fetal ductus arteriosus, resulting in persistent pulmonary hypertension in the newborn. Many people who read the above paragraph must be afraid, so don’t use it, safety first. Even so, many patients who desire to be mothers still dare to try the law on their own. As early as 1979, Crandon found that low-dose aspirin during early pregnancy reduced the prevalence of preeclampsia in pregnant women, and a large number of studies since then have suggested that there is no clear evidence that early aspirin exposure causes fetal abnormalities. There is no need to use aspirin in patients without the above indications. We often find that many patients use the drug on their own without the doctor’s permission, which is rather risky because aspirin can have side effects on the mother, mainly gastrointestinal bleeding or ulcers, bronchospastic allergic reactions, allergic skin reactions, and liver or kidney function impairment. Also aspirin has contraindications for use: ulcer disease with bleeding symptoms or other causes of active bleeding; hemophilia or thrombocytopenia.