Doctor: women repeatedly spontaneous miscarriage, it is necessary to have a closed antibody test Four miscarriages in eight years, always unable to keep the child, which makes Yang Min (a pseudonym) painful, almost a nervous breakdown. Recently, doctors said that some people always miscarry after pregnancy, probably because the couple HLA gene (human leukocyte antigen, closely related to the function of the human immune system, is the basis of the immune system to distinguish itself from foreign substances) similar, resulting in the mother can not produce closed antibodies or produce too little, reducing the protection of the embryo. Experts say that the causes of recurrent miscarriage are quite complex and about half of them can be identified, including genetic defects, anatomical abnormalities, endocrine abnormalities, immune factors, infections, systemic diseases and environmental factors. In addition, half of the causes are unknown, and there is a tendency to believe that at least 50% are related to immune factors. According to the experts, the lack of closed antibody is a very important factor in the immune factor, accounting for 50%. After the mother-to-be is pregnant, most of her body will produce a closed antibody, which can protect the normal growth and development of the fetus. However, some couples with similar HLA genes are unable to produce or produce too few closed antibodies due to the similarity of the major histocompatibility complexes, which can reduce the protection of the embryo and increase the chance of miscarriage. Yang Min is a case of lack of closed antibodies in her body. Experts recommend that if the cause of recurrent spontaneous miscarriage cannot be identified, it is necessary to undergo a closed antibody test. ”Ninety percent of patients with negative closed antibody tests resulting in infertility can successfully deliver a fetus through treatment.” Experts say that for such patients, active immunotherapy with the husband’s lymphocytes can be used, extracting lymphocytes from the husband’s blood and injecting them into the wife’s skin to stimulate her to produce closed antibodies, thus playing a role in protecting the fetus.