The best drugs for type 2 diabetes to reduce sugar are glucagon and insulin, and glucagon contains sulfonylurea and glargine. Type 2 diabetic patients are treated with oral hypoglycemic drugs based on reasonable diet and scientific exercise, and metformin is the first choice. When the blood glucose is not under control, it can be combined with one or more oral hypoglycemic drugs, such as pro-secretors, insulin sensitizers, sodium-glucose cotransporter 2 inhibitors, a-glucosidase inhibitors, dipeptidyl peptidase-IV inhibitors; patients with prolonged disease can be treated with or replaced by insulin.