Squamous cell carcinoma refers to malignant tumors originating from the squamous epithelium-covered areas, and keratinized type refers to the visible keratinized material in the cancer foci, which suggests that it is well differentiated. Malignant tumors originating from epithelial tissues are called “carcinomas”, among which those originating from squamous epithelial cell-covered areas are squamous epithelial carcinomas, which are most common in skin, esophagus, and cervix, and they can be either carcinomas of squamous epithelial cells or carcinomas of squamous epithelial cells that have undergone chemotaxis. The most superficial cells of normal squamous epithelium are keratinized, and well-differentiated squamous epithelial carcinoma will behave similarly to normal squamous epithelium. Therefore, keratinized squamous epithelial carcinoma can be divided into three categories: highly differentiated (keratinized), poorly differentiated (unkeratinized), and undifferentiated. Among them, the highly differentiated type, i.e. keratinized squamous epithelial carcinoma, is characterized by a stratified keratinized material visible in the center of the cancer nest. Keratinized squamous cell carcinoma is well differentiated and less malignant, and generally has a better prognosis. Patients are advised to adjust their mindset and actively seek further examination and treatment.