Multiple metastases of intrahepatic cholangiocarcinoma indicate that it is already in advanced stage and there is little hope of cure, but a series of treatments can be used to alleviate the corresponding symptoms and improve the quality of patients’ survival, such as palliative treatment, analgesic treatment, nutritional support therapy, and so on. 1. Palliative treatment: Symptomatic treatment cannot completely eradicate the tumor, but it can alleviate the patient’s symptoms, for example, when a large amount of ascites is formed and affects the respiratory function, it can be punctured and extracted; when the tumor causes bile duct obstruction and leads to jaundice, it can be placed in the bile duct stent, etc., so that the patient’s quality of life can be improved as much as possible. 2. Analgesic treatment: most of the advanced cancer patients have severe cancer pain and need long-term analgesic treatment. It is recommended to consult a pain doctor to formulate a long-term analgesic treatment plan to alleviate patients’ pain. 3. Nutritional support therapy: advanced cancer patients are suffering from severe malnutrition, so they can be given balanced diet, enteral nutritional support, parenteral nutritional support or albumin infusion if necessary, which can help prolong the survival period of the patients. 4. Other treatments: If the patient’s physical condition is still good, chemotherapy and targeted therapy can also be carried out. Chemotherapy drugs include cisplatin, paclitaxel and so on, and targeted therapy drugs include lenvatinib and so on. It is recommended that patients with advanced cholangiocarcinoma should go to the hospital as early as possible and receive appropriate treatment in time, which can help improve their quality of life and prolong their survival time.