The causes of rheumatic diseases are still unclear and may be related to genetic, infectious, environmental and immunologic factors. 1. Heredity: Rheumatic disease is a general term for more than 100 kinds of diseases, among which the onset of systemic lupus erythematosus, ankylosing spondylitis, rheumatoid arthritis and other diseases have family heredity. 2. Infection: Pathogens such as streptococcus, mycoplasma and viruses cause immune reactions, activate lymphocytes, secrete inflammatory factors, produce autoantibodies and lead to rheumatic diseases. 3. Environment: Long-term exposure to toxic chemicals or ultraviolet radiation may induce rheumatic diseases. 4. Immunity: If the function of normal immune cells of the patient is altered for some reasons, resulting in immune cross-reaction in the patient’s body, it will also cause rheumatic diseases. There are other reasons that may cause rheumatism, it is recommended that patients go to the rheumatology and immunology department of regular hospitals for detailed consultation.