High creatinine caused by hypertensive nephropathy can be divided into acute and chronic, acute can be restored to normal through active treatment of lowering blood pressure and protecting renal function, while chronic can not be restored in general, but active treatment can slow down the progression of the disease. Patients with hypertensive nephropathy have high blood creatinine due to poor blood pressure control, which leads to glomerular arteriosclerosis and renal insufficiency. Acute hypertensive renal damage through active treatment of renal function can be restored to normal, creatinine can be reduced to the normal range, chronic generally can not be restored, but active treatment can slow down the development of the disease. The emergence of hypertensive nephropathy needs to control blood pressure and oral treatment with renal drugs, commonly used blood pressure-lowering drugs are enalapril, benazepril, irbesartan, timosartan and so on. Blood pressure does not meet the standard can be combined with calcium antagonists such as nifedipine, amlodipine and so on. Drugs to protect renal function can be used at the same time, common drugs are Huangkui capsule, Renfukang capsule, Bailin capsule and so on. Whether hypertensive nephropathy with elevated creatinine can be recovered is related to the type of disease and whether it is actively treated, so it is recommended that patients consult nephrology department and actively treat under the guidance of physicians.