Patients can eliminate it through localized hot compresses or physical therapy. Progesterone can be used to treat menstrual disorders, amenorrhea, and functional uterine bleeding. It is mainly administered by intramuscular injection. If progesterone is injected in the same area for a long period of time, localized hard lumps may occur. Usually, such cases can be resolved spontaneously with the progress of time, and no special treatment measures are required. When injecting progesterone intramuscularly afterwards, it is necessary to change the site and avoid multiple injections in the same place, which is helpful to prevent the emergence of hard lumps. Some patients can use local hot compresses to promote the absorption of the medicine and eliminate the hard nodules. Physical therapy such as X-ray irradiation, electrotherapy and ultra-short-wave diathermy can also be taken to eliminate the hard nodules. During the treatment period, patients need to ensure sufficient rest time, do not overwork, maintain a positive and optimistic state of mind, to avoid tension, anxiety, any discomfort should be timely to the hospital, the doctor for a clear diagnosis, and cooperate with the doctor to deal with the symptoms.