Diuretics, as commonly used clinical drugs, can have a number of adverse reactions if used improperly, mainly in the following aspects: 1. Electrolyte disorders, such as hypokalemia, hyponatremia, hypochlorhydria, hypocalcemia, hypomagnesia Tend to be dose-dependent, that is, the higher the dose of diuretics used, the more likely hypokalemia occurs. Among the various diuretics, thiazide diuretics and tachyphylaxis cause more pronounced hypokalemia, and long-acting thiazide diuretics (e.g., chlorothiazide) are more pronounced than medium-acting hydrochlorothiazide. Hypokalemia tends to increase the risk of malignant arrhythmias and cerebrovascular accidents. In addition, it can also lead to low sodium, low chloride, low calcium and low magnesium. Therefore, when using diuretics, attention should be paid to monitoring blood electrolytes, adding potassium-protective diuretics or appropriate amount of electrolyte supplementation. 2. Hyperuricemia Studies have found that up to 30% of people with untreated hypertension have elevated blood uric acid. Diuretics can increase the reabsorption of uric acid by the kidneys and increase the risk of hyperuricemia, but rarely cause gout. 3. Abnormal glucose tolerance and insulin resistance See patients who use diuretics in high doses, which can easily induce diabetes. 4, lipid metabolism disorder Most of the reports of long-term application of hydrochlorothiazide can cause lipid metabolism disorder, mainly affecting the activity of lipase, so that triglyceride catabolism is reduced and triglycerides are increased; it can also cause mild cholesterol increase. However, in general, as long as it is used reasonably, the above-mentioned adverse reactions can be avoided, or the benefits far outweigh the disadvantages after use. Therefore, once the cardiologist gives the use, do not just stop using it, but should adjust the use under the guidance of the doctor.