The blisters caused by plasters can be treated with topical preparations and extraction of blister fluid in clinical treatment as follows: 1, 1:1000 potassium permanganate solution can be used to apply wet compresses for mild cases, and 3% boric acid solution can also be used to apply wet compresses; 2, the diameter of blisters is >1cm, and the wall of the blisters is thicker and the blisters are more full of blister fluid, so it is possible to use fire needles to quickly go into the affected area and release the blister fluid to achieve the therapeutic goal, and it is also possible to use aseptic syringes to extract blister fluid. 3.After the blister breaks out, you can use fusidic acid cream or compound polymyxin B ointment to carry on anti-inflammatory and antibacterial treatment, at the same time with the application of recombinant bovine alkaline fibroblast growth factor gel. The blisters caused by plastering may be contact allergy caused by the drug components contained in the plaster, or may be due to the preservatives, accelerators, hardeners and other compounds within the matrix of the plaster to cause an allergic reaction.