There is basically no recurrence of gallbladder cancer 10 years after mid-stage surgery, depending on the prognosis of the disease and the stage of gallbladder cancer. However, 10 years without recurrence already belongs to clinical cure and the chance of recurrence will be lower. Gallbladder cancer is a kind of malignant tumor of biliary system with relatively high malignancy degree. Cancer can be clinically cured by timely surgical resection treatment at early stage. If there is no recurrence after 10 years of surgical treatment in the middle stage, it should be considered as clinical cure. However, clinical cure is not a radical cure, so there is a certain chance of recurrence, but the chance is relatively low, and it is not easy to determine clearly whether it is a tumor recurrence or a newborn tumor. After surgical treatment of gallbladder cancer, patients need to avoid high-risk factors in daily life and go to the hospital for recheck regularly after treatment, and if there are uncomfortable symptoms, they should be treated in time.