Dapoxetine and lidocaine can be used together. Dapoxetine belongs to the selective 5-hydroxytryptamine inhibitor, which is a common medication for treating premature ejaculation in men. Dapoxetine tablets are metabolized faster in the body and mainly act on the central nervous system to improve the central nervous control of ejaculation, which can ultimately prolong the duration of sexual life. Dapoxetine side effects are mainly mild headache and nausea. It is contraindicated in patients with known hypersensitivity to Dapoxetine or any of the excipients. Lidocaine belongs to a kind of local anesthesia medication, which can be applied to the glans to block the sensory nerve conduction of the glans, reduce the sensitivity of the glans, and improve the quality of sex life. Therefore, the combined use of Dapoxetine and Lidocaine is more effective in treating premature ejaculation. Lidocaine can cause drowsiness, sensory abnormalities, muscle tremor, convulsive coma and respiratory depression and other adverse reactions. It is contraindicated in people who are allergic to local anesthetics. Intravenous use is contraindicated in patients with A. S. syndrome (acute cardiogenic ischemic syndrome), preexcitation syndrome, and severe heart block (including sinus, atrial, and intraventricular block). Dapoxetine is usually taken orally 1 to 3 hours before sexual intercourse and alcohol should not be consumed while taking Dapoxetine. Lidocaine is usually used 0.5 to 1 hour before sexual intercourse, which is evenly applied to the surface of the skin of the glans. The combination of the above medications needs to be done under a doctor’s supervision.