There is no specific data on the longest living time for the 2nd recurrence of grade 4 glioma, which is mainly related to the patient’s age, psychological quality, tumor site, etc., generally from half a year to one year. 1. Basic condition: if the patient is older, with poor physical quality, organs gradually aging, resulting in decreased immunity, after the 2nd recurrence of glioma, the clearance rate of human immune cells against mutated cells decreases, which generally has an impact on the survival time. 2. Tumor site: grade 4 glioma has a higher degree of malignancy, generally has strong invasiveness and metastasis, and is prone to metastasis after recurrence. Gliomas are often found in the lobes of the brain, the brain stem, and the cerebellar hemispheres. If the recurrence site is in the medulla oblongata and brainstem, it is usually difficult to have another chance of surgery, and the survival time of patients is shorter. 3. Psychological condition: the survival time of second recurrence of glioma is also related to the patient’s psychological condition, severe anxiety and depression will affect the subsequent survival time. Grade 4 glioma recurrence, should seek medical treatment in time, under the guidance of doctors.