What exactly should I do about bumps on the labia majora? The main thing is to find out what the cause of the long bumps is, such as genital herpes, which can appear as small grains of bumps on the labia majora. This situation can be topically applied with acyclovir ointment, oral antiviral medication, and then there is the wearing of loose underwear to avoid causing infection or pain. The bumps on the labia majora may also be caused by vestibular gland cysts. You can keep the area clean to avoid infection and wear loose pants to avoid squeezing and causing inflammatory reactions. In addition, surgery can be done if necessary. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. The actual fact is that you will not be able to have sex during the treatment period, which can be cross-infected. It is best to have a syphilis spirochete test and if it is positive (+), you can treat it with intramuscular penicillin.