There may be major side effects associated with taking Vesanin (generic name Denogestrel Tablets) for six months, but the exact side effects that occur and their severity vary from person to person. Dinogestrel tablets belong to the progestin class of drugs and are indicated for the treatment of endometriosis. Contraindications to the use of the drug include hypersensitivity to the product, active venous thromboembolic disease, current or previous arterial and cardiovascular disease, severe liver disease in which hepatic function values have not returned to normal, hepatic tumors, diabetes mellitus in the presence of vasculopathy, known or suspected sex-hormone-dependent malignant neoplasms, vaginal bleeding of unknown origin. Adverse effects of the drug involve several systems of the body, mostly in the first month after the start of treatment is the most common, with a gradual decrease with the continuation of treatment. 1. Gastrointestinal disorders: nausea, abdominal pain, bloating, and vomiting are common. 2. Metabolic and nutritional disorders: weight gain is common. 3. Psychiatric disorders: sleep disorders, depression, loss of libido, mood changes, and nervousness are common. 4. Systemic diseases: common weakness, irritability. 5. Skin and subcutaneous tissue disorders: acne, alopecia areata are common. 6. Reproductive and breast disorders: ovarian cysts, hot flashes (bouts of fever), uterine/vaginal bleeding (including spotting), breast discomfort are common. The occurrence of adverse drug reactions (type of occurrence, severity, etc.) is related to the individual’s constitution, so serious adverse reactions may occur after six months of taking the drug, but it varies from person to person and cannot be accurately predicted. Specific use of the drug should be carried out under the guidance of a specialist.