Patients with intermediate and advanced lung adenocarcinoma usually need comprehensive treatment, which mainly includes surgery, radiotherapy, chemotherapy, immunotherapy, targeted therapy and so on. 1. Surgery: If patients with middle-stage lung adenocarcinoma can undergo surgery, it is recommended to adopt surgery as early as possible to remove the lesions. 2. Radiation therapy: If surgical resection is not possible, radiation therapy can be prioritized. Lung adenocarcinoma is relatively sensitive to radiation therapy, and radiotherapy plan can be made according to the scope of lesions. Radiotherapy can be combined with immunotherapy or targeted therapy. 3. Chemotherapy: If patients with middle or late stage can accept chemotherapy, they can apply cisplatin, carboplatin, paclitaxel, docetaxel, pemetrexed disodium and other chemotherapeutic drugs under the guidance of doctors. Can be combined with immunotherapy 4. Immunotherapy: Immunotherapy is mainly for advanced patients, if the result of PD-1 test meets the requirement of immunotherapy, PD-1 and PD-L1 can be used for immunotherapy as prescribed by doctors, such as: karelizumab, sindilizumab, treplizumab. 5. Targeted therapy: If the patient’s genetic test result meets the gene type of targeted therapy, the patient can also follow the doctor’s instruction to take targeted drugs for treatment, such as: gefitinib, erlotinib, ositinib, crizotinib.