The pituitary gland is a very important central endocrine organ that secretes many hormones. The cause of high hormone secretion can be a lesion of the pituitary gland itself, such as a certain hormone of the pituitary gland, and the hormone-secreting cells proliferate and become tumors, growth hormone tumors increase growth hormone, and when you can’t grow as an adult, you grow organs, your chin grows, your tongue grows, your fingers grow, and your shoe size grows after you become an adult, which is caused by high hormones. There are also adrenocorticotropic hormone tumors and ACTH tumors, which cause adrenal hyperplasia. The adrenal glands secrete more hormones and cause centripetal obesity, thin limbs, large stomach, hypertension, and low blood pressure. In addition to the high secretion of pituitary hormones caused by long tumors in the pituitary gland itself, the pituitary gland is also governed by the hypothalamus. If the hypothalamus secretes more adrenocorticotropic hormone releasing hormone, it will cause more secretion of pituitary hormone, and more secretion of pituitary hormone will cause more secretion of lower target organs, which can cause systemic changes. In addition, if the target organs become dysfunctional, for example, in primary hypothyroidism, due to the impaired synthesis of thyroid hormone by the thyroid gland, the pituitary gland will compensate by secreting TSH to promote the synthesis of thyroid hormone. These are the three most common causes.