Paroxysmal nocturnal hemoglobinuria is paroxysmal sleep hemoglobinuria, this condition is more harmful. Paroxysmal nocturnal hemoglobinuria is a non-malignant clonal disease that clinically manifests itself as chronic intravascular hemolysis, recurrent thrombosis and hematopoietic failure. If this condition is not actively treated, serious complications such as infection, cerebral thrombosis, anemic heart disease, renal failure and even heart failure may occur, which can be life-threatening. Paroxysmal sleep hemoglobinuria can be controlled with medications such as dextrose, adrenocorticotropic hormone, and sodium bicarbonate to control episodes of hemolysis, and androgens (testosterone undecanoate) to stimulate blood cell production. Blood transfusions are also needed to raise hemoglobin and maintain normal tissue oxygen demand. When paroxysmal sleep hemoglobinuria is diagnosed, it is necessary to actively cooperate with the doctor for treatment in a timely manner to avoid delaying the condition and causing serious consequences.