Unstable angina is a more serious disease with a higher risk of progression to myocardial infarction, which can be called pre-infarction. More patients can directly induce heart failure, and some patients can die suddenly. Heart failure manifests as sudden shortness of breath at rest and accelerated respiratory rate. Acute left heart failure manifests as panic attacks, coughing, and coughing up pink frothy sputum. The prevention of sudden death in unstable angina mainly includes pharmacotherapy and hemodynamic reconstruction. Pharmacological treatment includes antiplatelet class, statin lipid-lowering drugs, and beta blockers. The cause of sudden death in unstable angina is ventricular fibrillation due to arrhythmia, which is related to sympathetic excitation. β-blockers can inhibit sympathetic excitation, reduce the occurrence of ventricular fibrillation and reduce the risk of sudden death. Blood flow reconstruction includes stent implantation and surgical bypass. The specific medication should be combined with the clinical situation and guided by the doctor’s face-to-face consultation.