Tumor metastasis to the brain is already at a relatively advanced stage, and if it is not treated, the general survival time is only a few months. With the progress of modern medical technology, some progress has been made in the treatment of brain metastases, and a large portion of brain metastases have significantly prolonged survival time after reasonable treatment, and many of them are also able to obtain several years of survival time. In some cases, the primary tumor of brain metastatic tumor is relatively clear, usually malignant tumors in other parts of the body have already been diagnosed through pathology, such as lung cancer, breast cancer, gastrointestinal cancer, melanoma, etc. In the process of treatment of these tumors, or even after several years of treatment, brain tumors are found, and brain metastatic tumors are highly suspected through magnetic resonance and other images. This part of brain metastases can be treated with chemotherapy or targeted therapy, radiotherapy or surgery depending on the size and number of metastatic lesions in the brain as well as the systemic condition. Generally speaking, if the size of the metastatic lesions in the brain is relatively small, radiotherapy can be chosen to control them, and there are suitable targeted drugs and other drugs that can be used to delay radiotherapy. If the volume is relatively large causing increased intracranial pressure, but the number of metastatic foci is relatively small, surgical resection of metastatic tumor foci can be used, which can quickly and effectively reduce intracranial pressure and carry out the follow-up comprehensive treatment. However, if the tumor is large and numerous, and the intracranial pressure increases, the tumor has already progressed to a rather advanced stage, and it is difficult to find effective treatments. If it is suspected by MRI or CT that the tumor has metastasized to the brain from other parts of the body, but the site of the primary tumor is not known, it is necessary to actively search for the primary tumor and evaluate the degree of harm it may cause to organs other than the brain. It is best to use relatively simple methods to clarify the pathological nature of the tumor. If the tumor has metastasized to the surface of the body or the lymph nodes can be punctured, it is a relatively simple method. However, if the tumor has already had a serious impact on other organs of the body and is difficult to control, the brain can only be treated with relatively conservative treatment options. If the tumor’s impact on other parts of the body is relatively small, and it is mainly the metastatic foci in the brain that threaten the patient’s life, then systemic drug therapy, radiotherapy or surgical treatment can be chosen according to the number, size and volume of metastatic foci in the brain, and these treatments can be chosen to control the intracranial pressure or neurological symptoms caused by the brain tumor as soon as possible, and at the same time, systemic anti-tumor therapy can be started as soon as possible. The treatment plan for tumor metastasis to the brain needs to have a global view, not only consider the brain, but also consider the harm of the tumor to other parts of the body. Tumor metastasis to the brain from other parts of the body is a common phenomenon of tumor progression, and the management of such patients needs to consider both the brain and other parts of the body in order to develop a reasonable treatment plan. This process also requires the participation of physicians from multiple disciplines working together.