Heartburn at night or in the middle of the night is considered to be indigestion, reflux esophagitis, gastric ulcer and other diseases, need to take medication, surgical treatment for the cause. 1. Dyspepsia: heartburn at night or in the middle of the night is considered to be caused by dyspepsia, the patient can take oral gastric power drugs under the guidance of the doctor, such as domperidone, mosapride, etc., and inhibit gastric acid drugs, such as lansoprazole, omeprazole and so on. 2. Reflux esophagitis: heartburn at night or in the middle of the night is also considered to be caused by reflux esophagitis. Patients can take acid-suppressing drugs such as famotidine and omeprazole orally as prescribed by the doctor. Promote the power of drugs, such as mosapride, domperidone, etc.. 3. Duodenal ulcer: heartburn at night or in the middle of the night may also be due to duodenal ulcer. Patients can take oral anti-Helicobacter pylori drugs, such as clarithromycin, amoxicillin omeprazole, lansoprazole, bismuth potassium citrate. There are many causes of heartburn at night or in the middle of the night, and patients are advised to go to regular hospitals to find out the cause. Symptomatic treatment.