Introduction to Meningioma and Frequently Asked Questions

  Meningioma is a derivative originating from meninges and meningeal gaps, mostly from arachnoid cells, and is one of the most common tumors of the central nervous system, accounting for 15% to 24% of intracranial tumors, 97% of which are benign.  Etiology: It is still unclear, and studies have shown that its occurrence may be related to internal environmental alterations, genetic mutations, trauma, viral infections, etc. The latest WHO (2000) pathological staging classifies meningiomas into 15 subtypes, of which epithelial and fibrous types are the most common, atypical ones require radiotherapy, and mesenchymal or malignant meningiomas are prone to recurrence. The adjacent skull is often thinned by tumor pressure or the bone plate is destroyed, and sometimes a localized elevation of the scalp is seen, which may also thicken the endosteal plate, and the thickened skull may contain tumor tissue.  Clinical manifestations: The peak age of meningioma onset is around 45 years old, with more females. Generally, the tumor grows slowly, has a long course, and has no specific clinical manifestations in the early stage, but may have chronic headache, nausea and vomiting, or sudden convulsions. Depending on the location of the tumor, clinical manifestations may include visual or auditory disturbances and weakness of limbs. The common sites are parsagittal sinus, cerebral convexity, pars falciformis, followed by pterygoid crest, saddle node, bromal sulcus, cerebellar pontine angle and cerebellar curtain, etc. Those growing in the ventricles are rare and can also be seen in the epidural area. There are also ectopic meningiomas, occasionally seen in the cranial plate barrier, frontal sinus, nasal cavity subscalp or neck, which come from ectopic arachnoid tissue and are not metastases. Meningiomas are multiple, accounting for about 1% to 2%, and can be as many as dozens.  Diagnosis: CT and MRI are common and reliable means of diagnosing meningioma. 15% of meningiomas are associated with atypical necrosis, cystic changes or hemorrhage, and enhancement can help differentiate meningioma from other tumors; MRI can also show the caudal sign of meningioma, which can help complete resection of the tumor and reduce the chance of recurrence.  Treatment: Surgical resection is the only curative method for meningioma. In principle, complete resection and removal of the meninges and bone invaded by the tumor should be pursued for radical treatment. Most meningiomas are benign. If early diagnosis can be made, surgery before the tumor damages the surrounding brain tissue and important cranial nerves and blood vessels should be able to achieve total resection. Small meningiomas should be resected early, because the tumor will easily invade important structures after growth, making surgery difficult and increasing complications and mortality. Some of the larger tumors, especially deep meningiomas, are closely adherent or encapsulated with important structures such as nerves and blood vessels, so it is appropriate to perform subtotal resection of the tumor to relieve intracranial pressure and protect function, or to deal with it by staged surgery.  Due to the different growth sites of tumors, about 17% to 50% of meningiomas cannot be completely excised, as well as a few malignant meningiomas need postoperative radiotherapy. Malignant meningioma is sensitive to radiotherapy with positive results. Studies have shown that radiotherapy can reduce the recurrence rate of meningioma from 74% to 29%. Gamma knife (γ-knife), X-knife and radiotherapy have similar effects.  Prognosis: Meningiomas of the convex surface of the brain and parafascicular meningioma generally have a good prognosis, with few postoperative complications and a surgical mortality rate of 1% to 2%, while deep and skull base meningiomas have relatively more postoperative complications.  Postoperative common problems: 1. Postoperative headache: Patients may have various kinds of headaches for a period of time after surgery, which are generally related to postoperative edema. Generally, the degree of headache is not significantly aggravated or gradually relieved, indicating that the edema is subsiding. There are also some people with vascular headache. Such patients need to relax their emotions and actively adapt to their surroundings, and serious cases can apply drugs to help relieve them. If the nature of headache is not relieved for a long time, or appears to be aggravated, or aggravated after relieving, it is necessary to seek medical attention to further clarify the cause.  2.Postoperative fever: Patients may have low fever 3-5 days after surgery, which is generally considered as absorption fever and can improve on its own. However, if high fever does not subside, infection is considered and medication is needed. Patients with infection can usually be cured after active medication in the hospital. A small number of patients who develop fever after discharge (within 1 week) still need to be alerted because some patients have delayed manifestations of infection or subcutaneous pus accumulation around the incision. Patients with fever should go to hospital for further examination.  3, postoperative convulsions: convulsions are one of the common postoperative complications, and most of them without convulsive seizures can be gradually reduced to discontinued. Some patients need to take medication for a long time, should reduce the medication under the guidance of the doctor, do not reduce the dose or discontinue it privately.  4.Neurological deficit: The functional deficit is mainly related to the tumor site and size, for example, meningioma near the central sulcus is prone to hemiparesis after surgery, which requires postoperative rehabilitation, and most patients can recover after active exercise when the edema subsides; meningioma of the pontocerebellar horn is prone to transient facial palsy after surgery, and most patients recover after active rehabilitation when the nerves are intact.  5.Radiotherapy: For those with mesenchymal or other malignant meningioma, further radiotherapy is needed. Radiotherapy should be carried out under the guidance of doctors and should not be neglected or abandoned because of radiotherapy reaction.  6.Recurrence: Due to the location of the tumor or multiple meningioma patients, or malignant meningioma patients have a high chance of recurrence after surgery, regular review and follow-up are required, and those with significant enlargement need to be operated again.