Low-grade endometrial mesenchymal sarcoma stage 2 is still serious and needs to be treated as soon as possible. Low-grade endometrial mesenchymal sarcoma stage 2 is a malignant tumor, but because it is low-grade, the progression of the disease is relatively not particularly fast, but it should be treated as soon as possible. Low-grade endometrial mesenchymal sarcoma often manifests as irregular vaginal bleeding, vaginal discharge, menorrhagia, lower abdominal pain and other symptoms. Endometrial mesenchymal sarcoma is very sensitive to radiotherapy, which can effectively control tumor growth and reduce distant metastasis in order to improve women’s quality of life. Surgery is also a treatment method for low-grade endometrial mesenchymal sarcoma, and it is preferred if it meets the indications for surgery. In clinical practice, it is recommended that patients with low-grade endometrial mesenchymal sarcoma stage 2 should go to the hospital for treatment in time to avoid delaying their condition.