Renal biopsy puncture visible 21 glomerular abnormalities generally only indicates the presence of glomerulopathy and cannot be correctly diagnosed. The specific condition of glomerular disease needs to be analyzed in combination with the pathologic pattern on the pathology report card, immunofluorescence and other specific analyses in order to make an accurate and definite diagnosis, to determine the appropriate treatment plan, and to judge the extent of renal lesions and whether they can be recovered. Renal biopsy puncture is to puncture the renal parenchyma percutaneously through a puncture needle, bring out a small amount of specimen of diseased kidney, observe the morphology under light or electron microscope, and carry out immunological analysis, which is one of the important diagnostic means of glomerular diseases at present. Renal puncture biopsy provides clinicians with a basis for diagnosing the type of kidney disease, determining the extent and degree of the lesion, guiding the patient as to what nature of treatment is appropriate, and assessing recovery from treatment. There are many indications for renal biopsy puncture, such as undiagnosed acute progressive nephritis, primary nephrotic syndrome, unexplained hematuria, lupus nephritis, unexplained acute kidney injury, transplantation of kidney disease, etc. Doctors need to refer to the biopsy report in order to make an accurate judgment of the condition. Patients with 21 glomerular abnormalities on renal biopsy are recommended to follow the doctor’s instructions for standardized treatment.