Renal failure is divided into acute and chronic, so it is important to find the cause, part of the acute renal failure can be cured, chronic renal failure can not be cured no matter using Chinese or Western medicine treatment, need to apply long-term drugs for control to slow down the progression of renal function damage. Western medicine treatment is mainly given ACEI, ARB drugs to reduce urinary protein, but should be used with caution when the blood creatinine rises to more than 250 μmol/L, so as not to cause hyperkalemia. In addition, essential amino acids such as α-keto acid can be given to improve protein metabolism and correct malnutrition, while diuretic, decongestive, and myocardial blood supply drugs can be given for treatment. When combined with renal anemia, erythropoietin can be applied to correct the anemia. Chinese medicine treatment commonly used are urethral granules, renal failure capsules and other drugs containing rhubarb preparations, to promote the excretion of toxins from the intestinal tract, but also can be used to improve the symptoms of Chinese medicine enema. When the disease progresses to end-stage renal disease, renal replacement therapy, including hemodialysis, peritoneal dialysis and kidney transplantation, is required.