Epigastric pain in the left middle and right abdomen may be due to physiological factors such as diet, or gastrointestinal diseases, liver and gallbladder diseases, urological diseases and so on. 1. Physiological factors: when eating too fast, too much, too spicy, or overeating, it will produce stimulation of the gastrointestinal mucosa, resulting in the patient’s epigastric pain in the left middle and right abdomen. 2. Gastrointestinal diseases: such as peptic ulcer, chronic gastritis, gastric cancer and other diseases, during the attack will lead to the patient’s epigastric pain, which will be accompanied by abdominal distension, acid reflux, belching, loss of appetite and other symptoms. 3. Hepatobiliary diseases: such as viral hepatitis, fatty liver, cirrhosis, liver cancer, cholecystitis, gallbladder stones, etc., which can cause vague pain in the epigastric left, center and right abdomen. Patients may also have symptoms such as fatigue, anorexia and jaundice. 4. Urological diseases: such as kidney stones, can also cause epigastric pain in the abdomen, which can be accompanied by hematuria, irritability, abdominal distension and other symptoms. There are many other causes of epigastric pain, if the patient has long-term or recurrent symptoms of epigastric pain, it is recommended to consult a doctor in a timely manner, and actively receive treatment. Drugs must be taken strictly in accordance with the doctor’s instructions, not self-medication, so as not to delay or even aggravate the condition.