Total serum cholesterol is the sum of cholesterol contained in all lipoproteins in the blood, including free cholesterol and cholesteryl esters. The range of the test varies from hospital to hospital due to different kits and instruments, but generally the normal range of total cholesterol is 3-5.2 mmol/L. Total cholesterol of 5.4 mmol/L is mildly elevated, and if there are no clinical symptoms or organic diseases, it is most likely caused by long-term consumption of high cholesterol foods. The total cholesterol can be lowered by adjusting the diet structure and appropriate aerobic exercise, such as avoiding animal offal and fatty meat, avoiding alcohol, and eating mainly soy products, dairy products, fruits and vegetables; doing exercises such as jogging, brisk walking, swimming and cycling. If the total cholesterol does not drop significantly through the above methods, oral statin lipid-lowering drugs should be considered, commonly used drugs include resulvastatin and atorvastatin. If hypothyroidism is present, oral levothyroxine sodium tablets should be considered at this time. If the total cholesterol is high due to hepatocellular damage and obstructive jaundice, the primary disease should also be treated aggressively, and liver-protective and anti-yellowness drugs such as compound glycopyrrolate and adenosylmethionine should be considered, and surgery may be required if necessary.