SLE is a disease with a high incidence among connective tissue diseases, mostly occurring in women during their reproductive years. The disease can affect almost every system and organ of the body, including the kidneys, gastrointestinal tract, liver, and neuropsychiatric system, posing a great threat to patients’ health. The clinical course of the disease can often be characterized by edematous erythema on both cheeks, such as a butterfly-like rash. Director Liu Yongnian believes that because of the characteristic clinical manifestations of SLE, many similar records can be found in ancient Chinese medical literature, such as “Yin Yang Poison”, “Wu Ying Dan”, “Red Butterfly Spot “, “red-faced wandering wind”, “Yang poison hair spots”, “warm poison hair spots”, “pig-eye sores “, “ghost-faced sores” and so on, which have provided rich literature for the treatment of lupus erythematosus in Chinese medicine. Most ancient people already recognized the disease as a systemic disease rather than a mere skin damage, but due to the limitations of the means of understanding at that time, it was not possible to recognize the complexity of the late stages of SLE involving the internal organs of the whole body and the alternation between the exacerbation and remission periods. The onset of SLE is the result of a combination of intrinsic endowment with toxicity (heat) and stasis. The relationship between deficiency and toxicity (heat) and stasis should be identified in the treatment. The skin erythema is one of the most common clinical symptoms. It is generally believed that it is caused by poisonous heat attacking the blood and blood circulation, heat injuring the blood channels, blood-heat overflowing, stagnating the muscle couples, or burnt by both qi and ying, but it should not be ignored that it is caused by deficiency of yang qi, weakness of pushing, blood clotting, stagnation of qi, stasis of veins and channels, or blood stasis with phlegm, blocking the meridians. The deficiency is caused by Yin deficiency of liver and kidney, Yang deficiency of spleen and kidney, stasis of heat and toxicity, and phlegm and stagnation. Therefore, it can nourish the liver and kidney, warm the spleen and kidney, or clear heat and detoxify, resolve phlegm and eliminate stasis. Commonly used drugs are xuan ginseng, water hyacinth, danpi, red peony, comfrey, ghost arrow feather, earth poria, big black bean, snake tongue grass, mung bean coat, etc. The current means and drugs used in Western medicine to treat SLE are mostly based on correcting the dysfunction of the immune system, such as using glucocorticoids, methotrexate, cyclophosphamide, azathioprine and other drugs to suppress and regulate the disordered immune system, and even biological agents such as antigen complexes, cytokines and even stem cell transplants for MHC. However, so far, glucocorticoids are still the most powerful drugs with immunosuppressive effects and the most commonly used drugs. However, because glucocorticoids have more side effects, such as they can cause infection, osteoporosis, diabetes, osteonecrosis and hypertension, the rational use of hormones is very important. The combination of Chinese medicine and hormones to reduce the side effects of hormones is also one of the advantages of Chinese medicine in the treatment of SLE. Patients in the early stage of hormone use may show signs of yin deficiency and fire, such as irritability of the heart, dry mouth and throat, red tongue with little moss and thin pulse, etc. Patients in the process of long-term hormone use or hormone withdrawal often show signs of yang deficiency, such as fear of cold, lack of warmth in the hands and feet, and clear and long urine, etc. When the yin deficiency can be appropriately supplemented with Chinese medicine, Sha Shen, Mai Dong, Yu Zhu, Wu Wei Zi, especially some tangible products of flesh and blood, such as turtle plate and turtle nail, etc., and heat signs can be added. For yin deficiency, we can add Cuscuta sinensis, Xianmao, Ba Ji Tian, etc. Due to the irreplaceable role of hormones in the treatment of SLE, the treatment should be combined with Chinese and Western medicine, only in this way, it is possible to minimize the side effects of drugs, delay the process of lesions and improve the quality of life of patients.