Cushing’s ulcer, or Cushing’s ulcer, is a stress ulcer of the gastrointestinal tract associated with intracranial hypertension. In addition to occurring in the stomach, they can also occur in the proximal duodenum and distal esophagus. The pathogenesis of Cushing’s ulcer, is an increase in intracranial pressure, which directly stimulates the vagus nerve, and the stimulation signal is released to the receptors of the gastric wall cells, in the form of acetylcholine, through the efferent fibers of the vagus nerve, resulting in increased secretion of gastric acid in the stomach, which stimulates and damages the gastric mucosa, duodenal mucosa and esophageal mucosa, causing ulceration of the gastrointestinal mucosa. Cushing’s ulcer, frequently occurs in patients with shock, sepsis and traumatic brain injury. Diagnosing a Cushing’s ulcer therefore requires consideration of the patient’s medical history and requires gastrointestinal endoscopy and angiography to determine the site of the lesion and the severity of the ulcer. If the Cushing’s ulcer is deep, it can easily cause perforation.