During the follicular phase of the normal menstrual cycle, the average serum testosterone concentration is 0.43 ng/ml, with a high limit of 0.68 ng/ml. If it exceeds 0.7 ng/m1 (equal to 2.44 nmol/L), it is called hypertestosteronemia, or hyperandrogenemia. The main androgens in the blood circulation are dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), androstenedione (Δ4A), testosterone (T), and dihydrotestosterone (DHT), etc. Due to some diseases or factors in the patient’s body that cause excessive blood androgens, which in turn lead to hypertestosteronemia, the clinical Therefore, it is better to find out the cause of high blood androgens to find the most direct cause of hypertestosteronism. Etiology of significantly elevated serum testosterone concentration: 1. Due to ovarian or adrenal cortex overproduction. 2. 2. It may also be caused by abnormal peripheral transformation. 3, is in the steroid hormone biosynthesis process enzyme system disorders, such as aromatase deficiency, androstenedione can not be converted into estrone, testosterone also can not be converted into estradiol, resulting in androstenedione, especially testosterone accumulation of excessive. 4. 60% of testosterone is bound to beta globulin in the blood, called testosterone-estradiol binding globulin (TEBG), and about 38% (mainly androstenedione) is bound to albumin, while free testosterone accounts for only 2%, but it is active. If TEBG binds more estradiol and binds less testosterone, free testosterone in the blood increases. 5. Hyperinsulinemia caused by insulin resistance can stimulate the ovaries to secrete large amounts of androgens, and these excess androgens turn to lead to the development of hypertestosteronemia.