There is no optimal drainage method for ascites in advanced stage of liver cancer, and individualized treatment suitable for patients can be better. Commonly, there are abdominal puncture and drainage, taking some targeted drugs such as sorafenib to control ascites, or entering albumin and adding some diuretics under doctor’s guidance to drain the ascites. In advanced stage of liver cancer, due to portal hypertension as well as hypoproteinemia leading to excessive amount of ascites, there will be compression symptoms, which can be improved by supplementing some albumin, improving the symptoms of hypoproteinemia, reducing the generation of ascites, strengthening the patient’s nutrition, and liver-protecting treatments (e.g. magnesium isoglycyrrhizinate, reduced glutathione). In addition, ascites in advanced stage of liver cancer can be discharged as soon as possible through abdominal puncture, which can relieve the patient’s symptoms short-term to a certain extent. As liver cancer is a malignant tumor, ascites may recur again within a certain period of time, and regular puncture and drainage is needed to improve patient’s symptoms. Patients with advanced liver cancer need palliative treatment under the premise of ensuring quality of life, and patients need to cooperate with doctors for standardized treatment.