Atrophic gastritis with erosion after 14 days of oral anti-Helicobacter pylori medication generally no longer need oral lansoprazole, if there is still discomfort it is recommended to consult a doctor in time to clarify the next step in the treatment program. Helicobacter pylori infection is a common cause of atrophic gastritis, so the treatment of atrophic gastritis should be the first eradication of Helicobacter pylori, the current recommendation is to use a quadruple drug, that is, proton pump inhibitors (such as rabeprazole), bismuth (such as colloidal bismuth pectin), antibiotics (such as amoxicillin, clarithromycin), the recommended use of medication for 10 days to 2 weeks. Generally, after 14 days of taking the quadruple medication, the medication is first discontinued for 1 month, and the breath test is repeated to evaluate the eradication effect of H. pylori, if the result is negative suggesting that the eradication is successful, and it is not recommended to continue the H. pylori treatment. If there is still discomfort, it is recommended to consult a doctor to determine the next step of treatment.