Hormone withdrawal syndrome is characterized by withdrawal symptoms and rebound phenomena. Long-term use of adrenocorticotropic hormone drugs will lead to a decline in the adrenocortical function of the patient, and when the drug is suddenly stopped or the dosage is reduced, hormone withdrawal syndrome will occur. 1. Withdrawal symptoms: long-term use of hormones, corticosteroid secretion is inhibited, if the drug is suddenly stopped, there will be withdrawal symptoms, manifested in weakness, nausea, vomiting, low blood pressure and other manifestations, and in severe cases, shock. 2. Rebound phenomenon: the symptoms can be relieved after using hormone therapy, but the original disease will recur or worsen after stopping or reducing the dosage. It is recommended that patients follow the doctor’s instructions to use the drug carefully and stop the drug under the guidance of the doctor.