Frequent urination in patients with advanced stage of lung cancer is usually related to mood tension, combined urinary tract infection or tumor metastasis to bladder, and according to the causes, they can choose psychological treatment, drug treatment, radiotherapy, chemotherapy and so on. 1. Stressful mood: if lung cancer patients develop to advanced stage and are too tense and anxious, they may urinate frequently, so they need to make some adjustments in terms of mood at present to avoid excessive fear and worry. 2. Combined urinary tract infection: some lung cancer patients are prone to combined urinary tract infection, such as cystitis, which may cause frequent urination. They need to insist on taking antibiotics to reduce inflammation, such as levofloxacin, while fighting against cancer. 3. Tumor metastasis to bladder: Lung cancer cells metastasize to bladder in advanced stage, which may cause frequent urination. At present, it is necessary to formulate chemotherapy program according to individual’s condition, and representative drugs include cyclophosphamide, adriamycin, epothilone, etc. Radiotherapy can be taken to inhibit cancer cells when necessary. When lung cancer develops into advanced stage with frequent urination, it is necessary to clarify the cause of the disease first and then carry out the treatment. During the treatment, patients need to put balance in their mind and actively cooperate with doctors, which can prolong the survival time and improve the quality of life.