Amyloidosis is categorized into cutaneous amyloidosis and systemic amyloidosis, the former has no effect on life expectancy, while the latter has a survival time ranging from a few years to a few decades depending on the individual patient. 1. Cutaneous amyloidosis: There are no obvious symptoms in the early stage of cutaneous amyloidosis, and occasionally brown spots and papules as big as a pinhead will appear on the skin, which lacks typicality. With the progress of the disease can appear hemispherical, polygonal or conical hard papules, generally take drug treatment. Cutaneous amyloidosis has a good prognosis and does not affect the patient’s health or life expectancy. 2. Systemic amyloidosis: it mostly occurs in the elderly over 40 years old, usually with unexplained weight loss, fatigue and other clinical manifestations, often involving the heart, liver, kidneys and other organs, affecting the life expectancy of patients. Survival time is related to the patient’s personal situation, ranging from a few years to decades. Patients are advised to go to the hospital for treatment as soon as possible. It is recommended to consult a doctor in time for amyloidosis and follow the doctor’s instructions for treatment.