Stellate ganglion block is a relatively common operation in pain management and has been widely used to treat various diseases, but there are few reports on the treatment of breast diseases. In our pain clinic, we have used bilateral stellate ganglion blocks starting 11 days after menstruation for patients with clearly diagnosed mastopathy and cystic hyperplasia of the breast, with one injection in 3 days and a course of 4 injections. The possible mechanisms are: a. The administration of stellate ganglion block can significantly increase the blood flow in the lesion area, improve the abnormal activity of vasoconstriction or diastole, release the vicious cycle of local ischemia and hypoxia caused by vasoconstriction and muscle spasm due to painful stimulation, and accelerate the transport and elimination of pain-causing substances, so the stellate ganglion block has pain-relieving, swelling-reducing, node-dispersing and anti-inflammatory effects. Therefore, stellate ganglion block has the effect of analgesia, swelling, nodule dispersal and anti-inflammatory. The normal growth and development of the breast is directly influenced, regulated and controlled by the hormones of the pituitary-ovarian axis, and the pathological changes of the breast are also closely related to the dysfunction of this system. Most breast diseases are related to the sex hormone metabolism of the body. Therefore, correcting and regulating endocrine disorders is the key to treating breast diseases, especially mastopexy. Stellate ganglion block has the effect of regulating endocrine disorders and nerve function, and the specific mechanism is yet to be further studied. The method of stellate ganglion block for the treatment of breast diseases has the advantages of clear anatomical structure, easy positioning and simple operation, which is worthy of clinical promotion under the premise of strengthening monitoring and equipped with resuscitation equipment. At the same time, strengthening psychotherapy and eliminating adverse mental stimulation are beneficial to patients’ early recovery.