A slight twitching at the corners of the mouth can also be clinically referred to as facial muscle spasm. In the case of facial muscle spasm, the first consideration is that it can be secondary to facial palsy, which causes adhesions to the nerve during the recovery period. Secondly, this kind of facial spasm can also be seen clinically in some patients with trigeminal neuralgia, where recurrent trigeminal neuralgia causes the patient to develop facial spasm. It can also be seen in some intracranial occupational diseases or some autoimmune diseases that lead to compression of the facial nerve by blood vessels in the course of travel. In this case, the cause should be identified, and treatment should be given for the cause, along with the oral administration of nerve-nourishing drugs. For example, vitamin B12, vitamin B6, methylcobalamin and so on. If necessary, acupuncture and massage can be used to relieve the condition. If the relief is not satisfactory, neurosurgery can also be consulted for surgical treatment. For facial muscle spasm caused by facial palsy, local cut-off treatment can be performed, and local closure treatment can also be given.