Methylprednisolone is a glucocorticoid drug with strong immunosuppressive, anti-inflammatory and anti-shock effects. Like other glucocorticoids, methylprednisolone also has some side effects, especially at high doses and when used for a long time, the following reactions can occur: 1. affect the body’s glucose and lipid metabolism, for example, it may cause an increase in blood sugar and fat, and it may lead to the redistribution of fat, for example, the increased fat may be more distributed on the face or back, and it is easy to have the special adverse reactions of using glucocorticoids, which we call full moon face and buffalo back. 3. Methylprednisolone may have certain stimulation to the gastrointestinal tract, and after using it, there may be 4. Methylprednisolone may affect the bones, if patients use it in large doses for a long time, it may lead to osteoporosis, and serious patients may suffer from femoral head necrosis. 5. Methylprednisolone liquid may affect the function of our liver, leading to an increase in transaminases. In conclusion, the side effects of methylprednisolone for injection are still relatively numerous, and the possible adverse reactions must be closely monitored during the process of use.