Progesterone is a natural progesterone secreted by the ovarian corpus luteum. In vivo, progesterone has a significant morphological effect on the estrogen-primed endometrium and is required for the maintenance of pregnancy. Progesterone is still routinely administered intramuscularly in high doses for progesterone support in most IVF centers. Long-term intramuscular injections of this drug often cause adverse effects such as redness, swelling, pain, and extravasation of the drug. How to mitigate the adverse effects is a major concern for all patients. Injectable progesterone is prone to hard nodules at the injection site, which can be applied locally with hot towels wet 12 hours after injection. Allergic reactions such as itching of the skin should be seen immediately, and the medication should be changed according to the condition at the appropriate time. Hot compress Hot compress should be applied 2-3 hours after intramuscular injection, 15-30 minutes each time with a hot towel wet compress, do not use hot water bags, electric heaters instead, because the effect of wet heat is more significant than dry heat. Do not apply hot compresses immediately after the injection. If you apply hot compresses immediately after the injection, harmful microorganisms will easily invade through the eye of the needle, causing inflammatory reactions such as redness, swelling, itching and pain. For patients who do not plan to transfer embryos in the cycle, you can also use magnesium sulfate powder diluted warm water wet compresses, the effect is better. 2. Potato slices patch with fresh potatoes washed and cut into 2-3mm slices after covering with intramuscular injections, external potato slices help to relieve the local hard knots caused by intramuscular progesterone, and has anti-inflammatory, pain relief, blood circulation and swelling function. Hot compress and potato slices to apply alternately.