Side effects of diuretics in advanced stage of hepatocellular carcinoma are hypokalemia, lipid metabolism, glucose metabolism, electrolyte disorders and so on. Patients with advanced stage of hepatocellular carcinoma are prone to generalized swelling and ascites, at this time, diuretics need to be given for symptomatic treatment, which can alleviate patients’ ascites, edema and swelling. However, side effects such as hypokalemia, lipid metabolism, glucose metabolism, electrolyte disorders and so on may occur when diuretics are used for a long time. Long-term use of diuretics such as hydrochlorothiazide can cause fat metabolism disorder and mild increase of cholesterol, which can be treated with lipid regulating drugs, such as simvastatin; long-term use of hydrochlorothiazide can also lead to the increase of fasting blood glucose, which can be used to reduce the dosage of the drug according to the situation; long-term use of diuretics can also lead to electrolyte disorders, such as hyperkalemia, hyponatremia, and so on, which need to be supplemented with electrolytes. If patients with advanced stage of liver cancer need to use diuretics, they should use them under the guidance of doctors, do not use them at will to avoid aggravating the condition.