Middle-differentiated adenocarcinoma of the small intestine is a relatively serious condition, but may have a good prognosis if treated relatively promptly. Middle-differentiated adenocarcinoma of the small intestine belongs to the relatively common malignant tumors of the small intestine, mostly found in the duodenum. If it is detected relatively early and does not infiltrate into the periphery, surgery is the treatment of choice. Including mesenteric and regional lymph nodes, radical surgery, most can get a good prognosis. If distant metastasis and lymphatic metastasis have already occurred, palliative surgery, adjuvant radiotherapy and chemotherapy can also achieve a good therapeutic effect. Patients should also be encouraged to build up confidence in treating the disease and actively cooperate with doctors.