Many eye diseases can cause blindness, common examples: keratitis, especially fungal keratitis, if the lesion happens to be in the pupil area, vision may be poor. Age-related cataracts, with clouding of the crystalline lens to grade 4 nuclear vision can be severely reduced, even to the point of having only manual or light-sensitive vision. With vitreous hemorrhage, vision can also be poor, even with only light or no light-sensitive vision. With fundopathy, central retinal artery blockage, vision can drop to light-less vision in seconds, while central retinal vein blockage is also painless vision loss. Age-related macular degeneration, which can also have poor vision and a poor prognosis for the effectiveness of treatment, are all fundopathies that can cause blindness.