One plus sign for routine urine protein, negative, refers to the possible presence of urinary protein as a routine urinary manifestation. First of all, quantitative urine protein test should be performed to clarify the presence of urine protein. If urine protein is present, this condition can be seen in pathological urinary tract infections, urinary tuberculosis and urinary stones and other related diseases, as well as in various types of primary and secondary nephritis, or nephrotic syndromes, such as lupus nephritis, diabetic nephropathy, thylakoid glomerulonephritis, membranous nephropathy and gouty nephropathy, or myeloma nephropathy. or myeloma nephropathy and other related diseases. In addition, a plus urine protein may also be associated with physical exercise, exertion, staying up late, heavy physical activity, sometimes prolonged standing, or a combination of upper respiratory tract infections, or gastroenteritis.