Abnormalities may be seen on a 24-hour ambulatory electrocardiogram if you do not sleep. If you do not rest for a long time, you may see abnormalities of ventricular pre-systole when doing a 24-hour ambulatory electrocardiogram. Ventricular pre-systole is one of the most common cardiac arrhythmias, which is easily induced by over-exertion, in addition to changes in the horizontal or downward sloping depression of the ST-segment of the ECG, etc. Staying up too late will also increase the risk of developing atrial fibrillation. In our daily life, we should pay attention to rest, avoid overwork, long-term late night will not only harm the cardiovascular system, for the human body nervous system and endocrine system will also have a negative impact on the human body, which will lead to high blood pressure, forgetfulness, endocrine disorders and other conditions.